饶毅：领先世界，形势喜人饶毅

读文献的46年来，以前是很少中国的论文，2000年后逐渐有，2015年以来可以见到的中国文章越来越多，但有很多跟风、还有不少垃圾。

不过，也有领先世界的。

1. Hao L, Midorikawa T, Ogasawara Y, et al. (2026). Reversible one-way lipid transfer at ER-autophagosome membrane contact sites via Atg2. Journal of Cell Biology 225:e202506039.

2. Sun J, Atiş IS, Empke SLL, Khokha MK, Breslow DK. (2026). A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology. Developmental Cell 61:687–705.e9.

3. Van de Heyning P, Van Rompaey V. (2026). Gene Therapy to Treat Profound Hearing Loss. New England Journal of Medicine 394:1126–1130.

4. Valayannopoulos V, Bance M, Carvalho DS, et al. (2026). DB-OTO Gene Therapy for Inherited Deafness. New England Journal of Medicine 394:1074–1083.

5. Sutton A, Alberts C, Xuan A, Minter N, Sanft A, et al. (2026). The Cell and Gene Therapy Access Model - A Vision for Future Development. New England Journal of Medicine 394:1046–1048.

6. Min C, Ezenwanne C, Dance Y, et al. (2026). Monocytes are biological sensors of aging and frailty in humans. bioRxiv 2026.03.10.710601.

7. Toro-Tapia G, Burbidge H, Biga V, et al. (2026). Ciliary cAMP regulates Shh signal interpretation to drive polarisation of differentiating neurons. bioRxiv 2026.03.11.711079.

8. Tao Y, Chu C, Cheng Z, et al. (2026). In vivo-directed evolution identifies AAV-WM04 as a next-generation vector for potent and durable hearing restoration in DFNB9. bioRxiv 2026.03.11.710960.

9. Vangelatou M, Stenboltk K, Bay S, et al. (2026). An optonanobody for reversible photoactivation of recombinant and native α7 nicotinic. bioRxiv 2026.03.10.710770.

10. Zanderigo EJ, Fatima M, Becker S, O'Neil AL. (2026). Alzheimer's Disease Brain Organoids as a Source of Disease Relevant Amyloid-Beta Oligomers. bioRxiv 2026.03.09.710594.

11. Y Zeng, X Hu, Z Hu, et al. (2026). Instantaneous Beta Frequency Regulates Self-Generated Timing in Humans. bioRxiv 2026.03.10.710730.

12. Zheng C, Hervé B, Meijer M, et al. (2025). Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis. Nature Neuroscience 28:2612–2627.

13. Smith BA, Meeks CB, Murray-Brown I, et al. (2025). Balancing brain exposure, pharmacokinetics and safety of transferrin receptor antibodies for delivery of neuro-therapeutics. mAbs 17:2592422.

14. Arafa D, van de Korput J, Braaker PN, et al. (2026). Myelin sheaths in the central nervous system can withstand damage and dynamically remodel. Science 391:eadr4661.

15. Monroe KM, Hong S, Lewcock JW, Yang AC. (2026). Therapeutic targeting of neuroimmune mechanisms in neurodegeneration. Nat Rev Drug Discov. 10.1038/s41573-025-01370-7. Advance online publication.

16. Boivin M, Yu J, Eura N, et al. (2026). GGC repeat expansions within new open reading frames are translated into toxic polyglycine proteins in oculopharyngodistal myopathy. Nature Genetics 58:517–529.

17. Everall A, Tapinos A, Hawari A, et al. (2026). Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types. Nature Genetics 58:570–581.

18. Chan ICC, Zhang P, Pan X, et al. (2026). CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis. Nature Genetics 58:582–592.

19. Nordmann GC, Balay SD, Kapuruge TN, et al. (2026). A global screen for magnetically induced neuronal activity in the pigeon brain. Science 391:1155–1160.

20. Delaveris CS, Loudermilk RP, Pandey A, et al. (2026). Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer. Science 391:eaec1778.

21. Maher C, Saez I, Radulescu A. Decoding Covert Human Attention in Multidimensional Environments. bioRxiv 2026.03.11.710688.

22. PV Cherian, I Aviram, U Weill, et al. (2026). Trans-regenerational RNAi Memory in Planarians. bioRxiv 2026.03.11.711021.

23. Visconti di Oleggio Castello M, Guo J, Ma F, et al. (2026). Hyperface: a naturalistic fMRI dataset for investigating human face processing. bioRxiv 2026.03.11.711073.

24. Mary Louise Cramb K, Noor H, Thomas-Wright I, et al. (2026). Dopamine release from Parkinson's patient-derived neurons is disrupted due to impaired synaptic vesicle loading. bioRxiv 2026.03.11.711038.

25. Chauvin RJ, Zheng A, Metoki A, et al. (2026). Brain organization of a memory champion. bioRxiv 2026.01.11.698919.

26. Carlson RJ, Taiber S, Rubinstein JT. (2025). Gene Therapy for Hearing Loss: Which Genes Next?. Otology & Neurotology 46:239–247.

27. Du S, Ou F, Drieu A, et al. (2026). Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. Neuron, S0896-6273(26)00057-7. Advance online publication.

28. Godugu D, Gattu K, Suri P, Daartey AB, Jadhav K, Rojekar S. (2025). Nanobody Therapeutics in Alzheimer's Disease: From Molecular Mechanisms to Translational Approaches. Antibodies 15:1.

Reversible one-way lipid transfer at ER–autophagosome membrane contact sites via Atg2

Li Hao; Tomoki Midorikawa; Yuta Ogasawara ; Takuma Tsuji; Takuma Kishimoto; Yutaro Hama; Huichao Lang ; Nobuo N. Noda; Kuninori Suzuki

J Cell Biol March 2026, Vol.225(5), e202506039. doi: 10.1083/jcb.2025060

A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology

Jingbo Sun, Irem Sude Atiş, Stéfany L.L. Empke, Mustafa K. Khokha, David K. Breslow

Open Access

Sun et al. develop a microscopy-based CRISPR screening platform that combines ease of implementation with flexible analysis of live-cell or antibody-based markers. Screens in human cells using a series of ciliary molecular markers achieve high performance and reveal new ciliary regulators, including the conserved transition zone microprotein SMIM27/TZMP1.

Science behind the Study: Gene Therapy to Treat Profound Hearing Loss

P. Van de Heyning and V. Van Rompaey

N Engl J Med 2026;394:1126-113

DB-OTO Gene Therapy for Inherited Deafness

V. Valayannopoulos and Others

N Engl J Med 2026;394:1074-1083 | Published Online October 12, 2025

The Cell and Gene Therapy Access Model — A Vision for Future Development

A. Sutton and Others

N Engl J Med 2026;394:1046-1048 | Published Online March 7, 2026

Monocytes are biological sensors of aging and frailty in humans

Chanhong Min, Charles Ezenwanne, Yoseph Dance, Nicolas Macaluso, Ladaisha Thompson, Lolita Nidadavolu, Akhil Katuri, Crystal Szczesny, Jacqueline Langdon, Edward Pearce, Peter Abadir, Jeremy Walston, and Jude Marvin Phillip

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.10.710601

[Abstract] [PDF]

Ciliary cAMP regulates Shh signal interpretation to drive polarisation of differentiating neurons

Gabriela Toro-Tapia, Holly Burbidge, Veronica Biga, John Robert Davis, and Raman Das

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.11.711079

[Abstract] [PDF]

In vivo-directed evolution identifies AAV-WM04 as a next-generation vector for potent and durable hearing restoration in DFNB9

Yong Tao, Cenfeng Chu, Zhenzhe Cheng, Yilin Sun, Ying Chen, Huifang Zhang, Shuyue Bao, Boyu yang, Baoyi Feng, Xianyu Huang, Yao Lu, Qiuxiang Yang, Xuegao Mao, Qifang Zhou, Chenxi Jin, Zhuo Duan, Guisheng Zhong, and Hao Wu

bioRxiv posted 11 March 2026 doi:10.64898/2026.03.11.710960

[Abstract] [PDF]

An optonanobody for reversible photoactivation of recombinant and native α7 nicotinic

Maria Vangelatou, Kian Stenboltk, Sylvie Bay, Karima Medjebeur, Gabriel Ayme, Pierre Lafaye, arnaud Blondel, Alexandre Mourot, and Pierre-Jean Corringer

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.10.710770

[Abstract] [PDF]

Alzheimer's Disease Brain Organoids as a Source of Disease Relevant Amyloid-Beta Oligomers

Eric John Zanderigo, Manaal Fatima, Sandy Becker, and Alison Linsley O'Neil

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.09.710594

[Abstract] [PDF]

Instantaneous Beta Frequency Regulates Self-Generated Timing in Humans

Yitong Zeng, Xiangshu Hu, Zhenyi Hu, Jia Li, Qianyi Wu, Lu Shen, and Biao Han

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.10.710730

[Abstract] [PDF]

A global screen for magnetically induced neuronal activity in the pigeon brain

GREGORY C. NORDMANN HTTPS://ORCID.ORG/0000-0001-8840-7777, SPENCER D. BALAY HTTPS://ORCID.ORG/0000-0001-7322-2825, THAMARI N. KAPURUGE HTTPS://ORCID.ORG/0009-0008-2402-9189, MARCO NUMI, CHRISTOPH LEEB HTTPS://ORCID.ORG/0000-0002-7727-6246, SIMON NIMPF, E. PASCAL MALKEMPER HTTPS://ORCID.ORG/0000-0003-1099-0119, LUKAS LANDLER HTTPS://ORCID.ORG/0000-0002-5638-7924, AND DAVID A. KEAYS HTTPS://ORCID.ORG/0000-0002-8343-8002Authors Info & Affiliations

SCIENCE

20 Nov 2025

Vol 391, Issue 6790

pp. 1155-1160

DOI: 10.1126/science.aea6425

Decoding Covert Human Attention in Multidimensional Environments

Christina Maher, Ignacio Saez, and Angela Radulescu

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.11.710688

[Abstract] [PDF]

Trans-regenerational RNAi Memory in Planarians

Prakash V. Cherian, Idit Aviram, Uri Weill, Tamar Shapira, Sarit Anava, Hila Gingold, Jochen C. Rink, Oded Rechavi, and Omri Wurtzel

bioRxiv posted 13 March 2026 doi:10.64898/2026.03.11.711021

[Abstract] [PDF]

Hyperface: a naturalistic fMRI dataset for investigating human face processing